We're ready for Europe's top guns, says Cesc as Arsenal fall in Seville

Cesc Fabregas today shrugged off Arsenal's first loss in seven months, insisting: "We don't care. Bring on the best."

Last night's defeat at Sevilla ended the Gunners' 28-match unbeaten run but Fabregas is only too aware that this makeshift side were way below strength with captain William Gallas and striker Emmanuel Adebayor amongst those rested.

With his side comfortably through to the knock-out stages of the Champions League even before last night's clash, Spaniard Fabregas said: "Hats off to the boss to give a rest to the guys. Why not? Some of the squad are playing too much.

"We have three important games coming up and the league for us is the most important. We are qualified already.

"I don't care if we finish second in the group and have to play the big sides in the next round. If we want to be the best, we have to beat everybody.

"We have lost against a good side and that's it. We will try to win on Saturday."

Manager Arsene Wenger, facing a touchline ban after being banished from the bench, made seven changes from the team which beat Wigan on Saturday. They will finish-second in Group H if the Spaniards win away against Slavia Prague in a fortnight.

It wasn't a great night for Wenger, who refused to budge after being given his marching orders 10 minutes from the end for remonstrating with the fourth official.

Afterwards he said: "The fourth official was very busy tonight. I've been involved in over 100 games in the Champions League and his behaviour was shocking."

Eduardo put Arsenal ahead but Seydou Keita and Luis Fabiano replied before Freddy Kanoute's late penalty sealed it. Captain

Kolo Toure said of Dutch referee Eric Braamhaar: "I don't like to talk about the referee but he made things more hard for us. Everything he did was against Arsenal but when you go away, it is always like that."