Chelsea responded to the departure of Jose Mourinho by surging to a 3-1 victory against Sunderland at Stamford Bridge in the Premier League on Saturday, while Manchester United lost its second game in a row at home against Norwich.
Chelsea supporters repeatedly sang Mourinho's name as Branislav Ivanovic, Pedro Rodriguez and Oscar scored in an unexpectedly convincing victory.
In Manchester, Cameron Jerome and Alexander Tettey netted in each half as Norwich stunned United by recording a first win at Old Trafford since 1989.
Anthony Martial pulled one back for United in the 66th minute, the team's first shot on target, but Van Gaal's side managed only one more attempt that required a save.
Meanwhile, surprise Premier League leader Leicester beat Everton 3-2. Riyad Mahrez scored two penalties for Leicester before Shinji Okazaki got the decisive goal, while Romelu Lukaku and Kevin Mirallas scored for Everton.
Tottenham beat Southampton 2-0 at St. Mary's stadium to move fourth, above United.
Two goals in three first-half minutes from Harry Kane, on his 100th Tottenham appearance, and Dele Alli gave manager Mauricio Pochettino a win against his former club.
Tottenham moves fourth, above United on superior goal difference.
Crystal Palace beat host Stoke 2-1 thanks to a late winner from Lee Chung-yong in the 88th minute, while a resurgent Bournemouth also won 2-1 at West Bromwich Albion thanks to Charlie Daniels scoring a penalty in the 87th minute.
In Saturday's late match, Aston Villa came from a goal behind to draw 1-1 at Newcastle.
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