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Manchester United made two changes to the side that overcame Liverpool last weekend as Radamel Falcao returned to the starting XI.
The Colombia international came in for James Wilson as Darren Fletcher filled in for Marouane Fellaini, who is out through illness.
Angel di Maria and Rafael returned to the matchday squad but both were forced to settle for a place on the bench.
Ron Vlaar starts for the visitors for the first time since November 8 as Villa boss Paul Lambert made four changes.
Ahead of the game Louis van Gaal said he would not make a a decision on the future of Radamel Falcao in the near future.
"He hasn't played so much," Van Gaal said when asked about the possibility of signing Falcao.
"You cannot see too much of a player if he doesn't train so much.
"He has been injured a lot of time. First you have to be fit.
"Now he shows fitness in the training sessions so maybe I shall select him (for Saturday's game at Aston Villa), maybe for the bench or the line up. Let's wait and see."
Aston Villa: Guzan, Lowton, Vlaar (c), Okore, Clark, Cissokho, Sanchez, Delph, Weimann, Agbonlahor, Benteke.
Manchester United: De Gea, Jones, Carrick, Evans, Valencia, Fletcher, Mata, Rooney, Young, RvP, Falcao
