Mikel Arteta has been forced to make changes from the Arsenal team that drew 1-1 at Crystal Palace last week due to injury and suspension as the Gunners host high-flying Sheffield United.
Sead Kolasinac has a thigh problem and as a result 18-year-old winger Bukayo Saka comes in at left-back once again for today's clash at Emirates Stadium.
Sokratis has not made the 18-man squad, so Shkodran Mustafi partners David Luiz in cental defence.
In attack Arsenal will have to cope without Pierre-Emerick Aubameyang, who is serving the first of his three-game suspension after picking up a red card against Palace.
Arsenal squad 2019-20 | Injuries, contracts and squad numbers
Alexandre Lacazette leads the line and trusted with ending his goal drought, and is supported by Gabriel Martinelli, Nicolas Pepe and Mesut Ozil.
Hector Bellerin is back on the bench after returning from injury, while there is also room for Eddie Nketiah after the striker impressed enough in training.
Arsenal: Leno, Maitland-Niles, Luiz, Mustafi, Saka, Torreira, Xhaka, Pepe, Ozil, Martinelli, Lacazette
Subs: Bellerin, Ceballos, Holding, Martinez, Willock, Guendouzi, Nketiah
Sheff Utd: Henderson, Basham, Egan, O'Connell, Baldock, Lundstram, Norwood, Fleck, Stevens, McBurnie, Mousset
Subs: Sharp, Robinson, Jagielka, Kieron Freeman, Verrips, Osborn, Besic
Referee: Mike Dean
