The Prince of Wales and the Duchess of Cornwall will be with the Queen on Christmas Day, a Clarence House spokesman said.
It comes after the monarch confirmed she would remain in Windsor for Christmas amid the rapid spread of the Omicron variant of Covid.
The head of state normally hosts her large family at Sandringham in Norfolk over the holidays, and they are watched by crowds as they attend church on December 25.
The Queen was also forced to cancel the traditional pre-Christmas lunch with her extended family, which had been scheduled for Tuesday.
The 95-year-old has spent much of this year at Windsor Castle, where she and her late husband Philip, the Duke of Edinburgh, remained after Christmas while shielding throughout the lockdowns.
It is her first Christmas without her husband, who died last April. His funeral was held during Covid restrictions within the confines of the castle.
In October this year, the Queen was admitted to hospital overnight for preliminary investigations and ordered by her royal doctors to rest.
She was also ordered to spend time at home and step back from royal engagements, including the Remembrance Sunday service, after spraining her back.
During the 1960s, when the Queen’s children were young, many Christmases were celebrated at Windsor, but since 1988, when the castle was rewired, royal Christmases returned to Sandringham.
It has not yet been confirmed where the Duke and Duchess of Cambridge will be spending Christmas.
